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Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence

โœ Scribed by Huiping Zhang; Fatih Ozbay; Jaakko Lappalainen; Henry R. Kranzler; Christopher H. van Dyck; Dennis S. Charney; Lawrence H. Price; Steven Southwick; Bao-Zhu Yang; Ann Rasmussen; Joel Gelernter


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
89 KB
Volume
141B
Category
Article
ISSN
1552-4841

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## Abstract Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous __Bdnf__ knockout mice (__Bdnf__^+/โˆ’^) are hyperphagic, obese, and hyperactive; furthermore, central infusion of BDNF leads to severe, doseโ€