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Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway

✍ Scribed by P.J. Mulholland; N.T. Luong; J.J. Woodward; L.J. Chandler


Book ID
116788372
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
518 KB
Volume
151
Category
Article
ISSN
0306-4522

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN