✦ LIBER ✦

Brain-derived neurotrophic factor: A genetic risk factor for obsessive–compulsive disorder and Tourette syndrome?

✍ Scribed by Stefanie Klaffke; Inke R. König; Fritz Poustka; Andreas Ziegler; Johannes Hebebrand; Oliver Bandmann

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 52 KB
Volume: 21
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20849

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A strong association of the G196A polymorphism of the brain‐derived neurotrophic factor (BDNF) gene with obsessive–compulsive disorder (OCD) has been reported. Patients with Gilles de la Tourette's syndrome (GTS) often develop OCD as well, suggesting a shared genetic susceptibility for OCD and GTS. We investigated whether BNDF is associated not only with OCD but also with GTS. The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios. The extended transmission/disequilibrium test was applied. The transmission rates for both alleles did not differ from the expected transmission rates. This finding suggests that GTS and OCD may have distinct genetic risk factors. © 2006 Movement Disorder Society

📜 SIMILAR VOLUMES

The role of the brain-derived neurotroph

The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessive-compulsive disorder (OCD)

✍ Hilga Katerberg; Christine Lochner; Danielle C. Cath; Peter de Jonge; Zoltán Boc 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 147 KB 👁 2 views

Association study of a brain-derived neu

Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response

✍ Tsai, Shih-Jen ;Cheng, Chih-Ya ;Yu, Younger W-Y ;Chen, Tai-Jui ;Hong, Chen-Jee 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 56 KB 👁 2 views

The Val66Met polymorphism of the brain-d

The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: Evidence from a family-based association study

✍ Araceli Rosa; Manuel J. Cuesta; Mar Fatjó-Vilas; Víctor Peralta; Amalia Zarzuela 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 72 KB 👁 3 views

Mutation screen of the brain derived neu

Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder

✍ S. Friedel; F. Fontenla Horro; A.K. Wermter; F. Geller; A. Dempfle; K. Reichwald 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 71 KB 👁 3 views

## Abstract Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous __Bdnf__ knockout mice (__Bdnf__^+/−^) are hyperphagic, obese, and hyperactive; furthermore, central infusion of BDNF leads to severe, dose‐