𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Brain, CSF, and tumor pharmacokinetics of α-difluoromethylornithine in rats and dogs

✍ Scribed by Victor A. Levin; Judit Csejtey; Deborah J. Byrd

Publisher
Springer
Year
1983
Tongue
English
Weight
397 KB
Volume
10
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.

✦ Synopsis

We have determined the pharmacokinetic parameters for diffusion of alpha-[5-14C]-difluoromethylornithine (DFMO) from blood to brain, blood to cerebrospinal fluid (CSF), 9L rat brain tumor to adjacent brain, and blood to the subcutaneously-implanted 9L tumor in rats, and within the CSF of beagle dogs. DFMO diffusion across the blood-brain and blood-CSF barriers is quite restricted in both rats and dogs, but diffusion across the defective capillary system of both subcutaneous and intracerebral 9L tumors in rats is not. Under steady-state plasma conditions in rats, uptake of DFMO by the intracerebral 9L tumor and diffusion from tumor 5-6 mm into adjacent brain is not restricted; tissue/plasma ratios were approximately 1. Therapeutic efficacy will therefore not be limited by transport of DFMO into tumor or to the extracellular environment of tumor.

📜 SIMILAR VOLUMES

CNS toxicity and CSF pharmacokinetics of
CNS toxicity and CSF pharmacokinetics of intraventricular DFMO and MGBG in beagle dogs
✍ Victor A. Levin; Deborah Byrd; Julia Campbell; Richard L. Davis; Janice K. Borci 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 539 KB

We have developed a beagle dog model to study the pharmacology and toxicology of anticancer drugs administered through the 3rd or lateral ventricles. A Foltz-type reservoir was implanted SC and connected by tube into a cerebral ventricle. Drugs were administered directly into the reservoir; CSF samp

Brain regional pharmacokinetics of biper
Brain regional pharmacokinetics of biperiden in rats
✍ Koichi Yokagawa; Emi Nakashima; Junko Ishizaki; Mitsuru Hasegawa; Hideki Kido; F 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 501 KB

## Abstract The pharmacokinetic profiles of biperiden (BP) in blood and in specific brain regions were investigated in rats after acute i.v. administration. The regional brain‐to‐blood unbound concentration ratios (__K__~pf~) were also determined after 16h intravenous infusion of BP. The __K__~pf~

Pharmacokinetics of liquiritigenin in mi
Pharmacokinetics of liquiritigenin in mice, rats, rabbits, and dogs, and animal scale-up
✍ Hee E. Kang; Hye Y. Jung; Yu K. Cho; So H. Kim; Se I. Sohn; Seung R. Baek; Myung 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB

Pharmacokinetics of liquiritigenin (LQ) and its two glucuronide metabolites, M1 and M2, in mice, rats, rabbits, and dogs and animal scale-up of the pharmacokinetic parameters of LQ were evaluated. After intravenous administration of LQ, the AUC (AUC(0-t)) values of LQ, M1, and M2 were proportional t