Brain atrophy in children undergoing systemic chemotherapy for extracranial solid tumors

✍ Scribed by Prassopoulos, P.; Cavouras, D.; Evlogias, N.; Golfinopoulos, S.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 505 KB
• Volume: 28
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199703)28:3<228::aid-mpo15>3.0.co;2-a

✦ Synopsis

It has been shown that intrathecal chemother-Measurements were compared with corresapy may cause brain damage, which can be ponding normative data. About half of the childepicted in neuroimaging studies. The aim of dren undergoing chemotherapy and half of the this work was to examine possible morphologic patients examined after treatment were found alterations in the brain of children with extracra-to have diffuse brain atrophy. Focal lesions that nial solid tumors, without CNS complications, might be associated with therapy toxicity were treated with systemic chemotherapy. Brain CT not observed. Chemotherapy, even when adimages of 69 children with extracranial malig-ministered via the systemic route, may cause nancies were reviewed and the extent of 12 CSF brain damage, which is observed long after compartments was measured in 49 CT examina-the end of treatment. Med. Pediatr. Oncol. tions performed during intravenously given che-28:228-233 ᮊ 1997 Wiley-Liss, Inc. motherapy and in 20 after therapy completion.