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BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors

✍ Scribed by Eduardo Vilar; Judith Balmaña; Eloy Espín


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
40 KB
Volume
106
Category
Article
ISSN
0008-543X

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## Abstract ## BACKGROUND Alterations of __BRAF__ have been implicated in the carcinogenesis of colorectal tumors with microsatellite instability (MSI). These alterations were attributed to defective DNA mismatch repair, which underlies MSI. It was the objective of this study to clarify the role o