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Bradykinin induces a rapid cyclooxygenase-2 mRNA expression via Ca2+mobilization in human gingival fibroblasts primed with interleukin-1 β

✍ Scribed by S. Nakao; Y. Ogata; T. Modéer; M. Segawa; S. Furuyama; H. Sugiya


Book ID
114483285
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
168 KB
Volume
29
Category
Article
ISSN
0143-4160

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Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the