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Botulinum toxin for gastrointestinal disorders: Therapy and mechanisms

โœ Scribed by Harsha Vittal; Pankaj Jay Pasricha

Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
897 KB
Volume
9
Category
Article
ISSN
1029-8428

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Botulinum neurotoxin serotype A (BoNT/A) has revolutionised the treatment of a variety of autonomic hypersecretory disorders. Several open and controlled studies indicate that BoNT/A is a safe and effective treatment for focal hyperhidrosis of the axillae and palms, for gustatory sweating, and for s

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## Abstract In some patients, therapy with botulinum toxin type A (BTโ€A) becomes ineffective due to formation of antibodies (BTโ€Aโ€AB). The time course of BTโ€Aโ€AB titres after cessation of BTโ€A therapy was quantitatively studied to determine whether and when they might drop. Thirteen patients (eight