Botulinum toxin A injections improve apraxia of eyelid opening without overt blepharospasm associated with neurodegenerative diseases

✍ Scribed by Masato Kanazawa; Takayoshi Shimohata; Masahisa Sato; Osamu Onodera; Keiko Tanaka; Masatoyo Nishizawa

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 44 KB
• Volume: 22
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.21367

✦ Synopsis

Botulinum Toxin A Injections Improve Apraxia of Eyelid Opening without Overt Blepharospasm Associated with Neurodegenerative Diseases Apraxia of eyelid opening (AEO) designates an intermittent inability to open the eyes voluntarily. 1 AEO is observed in patients with neurodegenerative diseases, including progressive supranuclear palsy (PSP) and Parkinson disease. 1,2 Although AEO occurs in conjunction with blepharospasm, 1 it can occur in the absence of overt spasm of the orbicularis oculi. 3 Here, we report three cases of patients with AEO associated with spinocerebellar ataxias (SCAs) and Osler-Rendu-Weber disease (ORW) who did not show overt blepharospasm. We found that botulinum toxin A (BTX) injections improved AEO.