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Botulinum neurotoxins and the neuroexocytosis nanomachine

โœ Scribed by Montecucco, C.; Megighian, A.; Pantano, S.; Rigoni, M.; Rossetto, O.; Schiavo, G.; Scorzeto, M.; Zanini, D.; Zordan, M.

Book ID
122701603
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
55 KB
Volume
68
Category
Article
ISSN
0041-0101

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Structure and enzymatic activity of botu
Structure and enzymatic activity of botulinum neurotoxins
โœ Subramanyam Swaminathan; Subramanian Eswaramoorthy; Desigan Kumaran ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 244 KB

The structure of botulinum neurotoxin type B (BoNT/B) is analyzed, and it is demonstrated that the carbonyl oxygen of the scissile bond comes close to the zinc ion to form a Michaelis complex. The hydrated carbonyl is activated by the nucleophilic water, which moves closer to Glu 230 to form hydroge