Botulinum neurotoxin-A does not spread to distant muscles after intragastric injection: A double-blind single-fiber electromyography study
✍ Scribed by Maurizio Osio; Enrico Mailland; Francesco Muscia; Caterina Nascimbene; Alessandra Vanotti; Cristina Bana; Fabio Corsi; Diego Foschi; Claudio Mariani
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 84 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0148-639X
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✦ Synopsis
Abstract
The purpose of this study was to perform a careful neurophysiological examination to identify subclinical signs of botulinum toxin spread distant to the injection site following intragastric injection for obesity treatment. Single‐fiber electromyography of extensor digitorum communis and repetitive stimulation of abductor digiti minimi were performed before and 8 days after multiple intragastric injections of botulinum toxin A (Botox, 200 U per patient) or placebo. The study was performed in a randomized double‐blind fashion. No patient in either group displayed results indicative of neuromuscular dysfunction either before or after the treatment. No significant change in muscle jitter was observed when comparing baseline with the after‐treatment evaluation in either group, and no significant differences between groups were observed. After intragastric botulinum toxin injection no subclinical sign of distant spread was observed. Muscle Nerve, 2010