PMA and thrombin were examined for their ability to activate Naf/H+ exchange in growth-arrested WS-1 human fibroblasts. PMA or thrombin caused a cytoplasmic alkalinization that required extracellular sodium and was sensitive to 1 mM amiloride, suggesting that the rise in pH was mediated by the NaC/H
โฆ LIBER โฆ
Both protein kinase C and calcium mediate activation of the Na+/H+ antiporter in Chinese hamster embryo fibroblasts
โ Scribed by Sharon S. Ober; Arthur B. Pardee
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 715 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0021-9541
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Changes in intracellular ion concentrations have been correlated with the activation of an endogenous endonuclease and thus internucleosomal DNA cleavage during apoptosis in many cell types. We investigated whether intracellular pH could play a significant role in apoptotic initiation and progressio