Both Fcγ Receptor I and Fcγ Receptor III Mediate Disease in Accelerated Nephrotoxic Nephritis
✍ Scribed by Ruth M. Tarzi; Kevin A Davies; Jill W.C. Claassens; J. Sjef Verbeek; Mark J. Walport; H. Terence Cook
- Book ID
- 117022147
- Publisher
- American Society for Investigative Pathology
- Year
- 2003
- Tongue
- English
- Weight
- 332 KB
- Volume
- 162
- Category
- Article
- ISSN
- 0002-9440
No coin nor oath required. For personal study only.
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FccRIV is a relatively new IgG Fc receptor (FccR) that is reported to contribute to the pathogenesis of autoimmune diseases, although its specific role in relation to FccRIII, complement and IgG2 subclasses remains uncertain. Here we define FccRIV on macrophages as a receptor for soluble IgG2a/b com
## Objective: To study the role of the activating fc gamma receptor types i and iii (fc gamma ri and fc gamma riii, respectively) and the inhibiting fc gamma receptor ii (fc gamma rii) in inflammation and in various aspects of cartilage destruction during arthritis that is solely induced by immune