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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

✍ Scribed by Sun, Jiazhi; Qian, Yimin; Hamilton, Andrew D; Sebti, Saïd M

Book ID: 110061201
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 524 KB
Volume: 16
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1201656

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📜 SIMILAR VOLUMES

Inhibition of the prenylation of K-Ras,

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

✍ Lerner, Edwina C; Zhang, Ting-Ting; Knowles, David B; Qian, Yimin; Hamilton, And 📂 Article 📅 1997 🏛 Nature Publishing Group 🌐 English ⚖ 406 KB