Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells

Activation of the aryl hydrocarbon recep

Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells

✍ Jean-Marie Ramirez; Nicolò C. Brembilla; Olivier Sorg; Rachel Chicheportiche; Th 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 430 KB 👁 2 views

## Abstract Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating the effects of dioxin, favor Th17 differentiation and exacerbate autoimmunity in mice. We investigated how AHR ligands affected human T‐cell polarization. We found that the high affinity and stable AHR‐liga