✦ LIBER ✦
Boronic acid substituted viologen based optical sugar sensors: modulated quenching with viologen as a method for monosaccharide detection
✍ Scribed by Jason N Camara; Jeff T Suri; Frank E Cappuccio; Ritchie A Wessling; Bakthan Singaram
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 83 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
In our search for an optical glucose sensor we have found that the combination of pyranine 1 and a boronic acid substituted benzyl viologen (o-BBV, 2) signals monosaccharides in the range of 0-1800 mg/dL. The quenching ability of o-BBV is modulated upon sugar binding, which in turn alters the fluorescence of pyranine. The system utilizes a dye that is active in the visible spectrum, operates in aqueous solution at pH 7.4, and is highly sensitive to glucose in the physiological range.