Boron trichloride as an efficient and selective agent for deprotection of tert-butyl aryl sulfonamides

✍ Scribed by Yiqian Wan; Xiongyu Wu; Mahalingam A. Kannan; Mathias Alterman

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 125 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01020-7

✦ Synopsis

A fast, mild and selective method for deprotection of tert-butyl aryl sulfonamides utilizing BCl 3 as deprotection reagent has been developed. A variety of tert-butyl aryl sulfonamides used under these conditions gave the corresponding primary sulfonamides in high yields. The method does not cleave methoxy groups and prevents incorporation of tert-butyl groups onto electron-rich aromatic rings.