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Boron-Containing Polyamines as DNA Targeting Agents for Neutron Capture Therapy of Brain Tumors: Synthesis and Biological Evaluation

✍ Scribed by Cai, Jianping; Soloway, Albert H.; Barth, Rolf F.; Adams, Dianne M.; Hariharan, Joya R.; Wyzlic, Iwona M.; Radcliffe, Krista

Book ID
125990593
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
379 KB
Volume
40
Category
Article
ISSN
0022-2623

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Boron-Containing Polyamines as DNA Targeting Agents for Neutron Capture Therapy of Brain Tumors: Synthesis and Biological Evaluation
✍ Cai, Jianping; Soloway, Albert H.; Barth, Rolf F.; Adams, Dianne M.; Hariharan, πŸ“‚ Article πŸ“… 1997 πŸ› American Chemical Society 🌐 English βš– 379 KB

Three series of new boron-containing spermidine/spermine (SPD/SPM) analogues have been synthesized: N 1 -and N 5 -(4-carboranylbutyl) SPD/SPM derivatives (SPD-1, SPD-5, SPM-1, SPM-5); N 1 ,N 10 -diethyl-N 5 -(4-carboranylbutyl)spermidine (DESPD-5), N 1 ,N 14 -diethyl-N 5 -(4carboranylbutyl)spermine