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Borohydride reduction of periodate-oxidized nucleotides; isolation and structure of the reduction intermediate

✍ Scribed by Luann P. Rosenthal; Harry P.C. Hogenkamp; James W. Bodley

Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
505 KB
Volume
111
Category
Article
ISSN
0008-6215

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✦ Synopsis

The reduction of periodate-oxidized nucleotides with sodium borohydride proceeds via a reaction intermediate presumed to be a monoalcohol. The borohydridereduction intermediate of periodate-oxidized ADP has been isolated by anionexchange, liquid chromatography, and subjected to further reduction. Using sodium borohydride and sodium borodeuteride alternately in the two reduction steps, it was determined, by 'H-n.m.r.-spectral analysis, that the two aldehyde groups are sequentially reduced in the order 3' and 2', and it was concluded that the isolated intermediate corresponds to the semi-reduced, 3'-alcohol, 2'-aldehyde derivative. This compound should be a useful analog for the study of enzymes and proteins that interact with nucleotides.

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