Borohydride induced cleavage of azo derivatives of β-ketoesters. A useful variant of the Japp-Klingemann reaction for C-nucleoside synthesis.

✍ Scribed by Alan P. Kozikowski; William C. Floyd

• Book ID: 104240295
• Publisher: Elsevier Science
• Year: 1978
• Tongue: French
• Weight: 160 KB
• Volume: 19
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)88971-1

✦ Synopsis

The C-nucleosides, a group of molecules containing ribose bound to the carbon atom of a heterocyclic aglycone, exhibit significant antibacterial, antiviral and antitumor activity. 1 Our efforts to develop new routes to members of this group, such as the pyrazolopyrimidine nucleoside none 2, an forvcin (&I, without recourse to natural ribose are based intermediate whose synthesis has recently been disclosed. 2 * r;l-Ii k 1 /