Book Review: The Impact of Stereochemistry on Drug Development and Use. Hassan Y. Aboul-Enein and Irving W. Wainer (eds.), John Wiley & Sons Inc., New York, 1997, pp. xxvii + 695. ISBN 0-471-59644-2, US$99.00
✍ Scribed by Ronald F. Borne
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 17 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0269-3879
No coin nor oath required. For personal study only.
✦ Synopsis
A Series of Monographs on Analytical Chemistry and its Applications" edited by J. D. Wineforder. This contribution to the series consists of 23 chapters written by authors representing a broad international field. The goal of this book, as stated in the Preface, is to "give the reader some sense of the magnitude of the stereochemical revolution that has occurred in the past 15 years and an understanding of the maturity of this area of research". In this context this effort meets its goal. The initial chapter, written by one of the editors (H. Y. A-E), entitled "Chirality and Drug Hazards", sets the tone for the remainder of the book by briefly reviewing basic concepts of stereochemistry and relating the importance of chirality to pharmacological action. Subsequent chapters discuss the importance of stereochemistry in drug metabolism, drug action, and toxicity. Of particular interest to this review is Chapter 3, "Stereochemical Aspects of Drug Metabolism". Several chapters discuss chiral separations, preparation of drug enantiomers by chromatographic resolution, micelle-mediated capillary electrophoretic separation of enantiomers, enantioselective analysis and circular dichroism. Emphasis is placed on the importance of stereochemistry to the pharmaceutical industry in drug development. One chapter of particular interest in this regard is devoted to a review of current regulations for stereoisomeric drugs from the North American, European and Japanese points of view. Unfortunately, not all chapters will find general utility among the readership. Yet, overall this volume will be useful to those intimately involved in drug research and development and is particularly timely in view of the emerging importance of stereochemistry of drug development as emphasized by the Food and Drug Administration. The editors have attempted to overcome the shortcomings of many edited texts regarding lack of consistency in approach to the topic and overcoming language difficulties normally encountered in multiauthored, international collections.