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Bone sarcomas as second malignant neoplasms following childhood cancer

✍ Scribed by William A. Newton Jr.; Anna T. Meadows; Hiroyuki Shimada; Greta R. Bunin; Gordon F. Vawter


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
786 KB
Volume
67
Category
Article
ISSN
0008-543X

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Second malignant neoplasms following chi
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The risk of second malignant neoplasm (SMN) was evaluated in 979 children with Hodgkin's disease. This cohort was diagnosed between 1955 and 1979 at one of the institutions of the Late Effects Study Group. Solid tumors, non-lymphocytic leukemia, and non-Hodgkin's lymphoma (NHL) developed in 18, 17,

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## Abstract Many pediatric and adolescent cancer patients are treated with carcinogenic chemotherapeutic agents and radiation therapy to achieve permanent control of their malignancy. These modalities may induce a new cancer in the successfully treated patient. To identify disease and treatment fac

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## Abstract ## BACKGROUND Survivors of childhood malignancies have an increased risk of developing second malignant neoplasms (SMN) due to their prior treatment and/or genetic susceptibility. A small proportion of SMNs are soft tissue sarcomas (STS), whose prognosis is generally thought to be poor

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## Abstract A rare brain tumor (spongioblastoma polare) occurring 7 years after treatment of neuroblastoma stage IV S is reported. The literature concerning the occurrence of a second cancer in children exposed to mutagenic therapy for their initial tumor is reviewed, and genetic and environmental