During development, bone morphogenetic proteins (BMPs) induce the differentiation of mesenchymal progenitor cells to enter into the osteoblastic lineage, and BMPs enhance osteoblastic function. BMPs and noggin, a specific binding protein that blocks BMP actions, are expressed by osteoblastic cells b
โฆ LIBER โฆ
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
โ Scribed by Babitt, Jodie L; Huang, Franklin W; Wrighting, Diedra M; Xia, Yin; Sidis, Yisrael; Samad, Tarek A; Campagna, Jason A; Chung, Raymond T; Schneyer, Alan L; Woolf, Clifford J
- Book ID
- 109919348
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 317 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng1777
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Systemic and local factors regulate the activity of osteoblasts and osteoclasts during bone growth and remodeling by modulating a complex array of intracellular signaling events. Recent genetic evidence implicates extracellular fibrillin assemblies (microfibrils and elastic fibers) in imparting cont