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Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis Is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension

✍ Scribed by Wang, Yang-Kao; Yu, Xiang; Cohen, Daniel M.; Wozniak, Michele A.; Yang, Michael T.; Gao, Lin; Eyckmans, Jeroen; Chen, Christopher S.


Book ID
118034734
Publisher
Mary Ann Liebert
Year
2012
Tongue
English
Weight
955 KB
Volume
21
Category
Article
ISSN
1547-3287

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## Abstract Bone morphogenetic proteins (BMPs) have been shown to regulate both osteoblasts and osteoclasts. We previously reported that BMP2 could directly enhance RANKL‐mediated osteoclast differentiation by increasing the size and number of osteoclasts. Similarly, genetic deletion of the BMP ant