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Bone morphogenetic protein 2 increases insulin-like growth factor I and II transcripts and polypeptide levels in bone cell cultures

โœ Scribed by Ernesto Canalis; Bari Gabbitas


Book ID
112119375
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
876 KB
Volume
9
Category
Article
ISSN
0884-0431

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Glucocorticoids inhibit the proliferation, but induce the differentiation, of bone marrow stromal cells into osteoblast-like cells. The mechanisms, however, are still conjectural. Since insulin-like growth factors (IGFs) have profound effects on osteoblast growth and differentiation, it is possible