In the early embryonic heart, endothelial cells in atrioventricular (AV) and outflow tract (OT) regions are transformed into the invasive mesenchymal cells that form endocardial cushion tissue (endothelial-mesenchymal transformation). It has been reported that bone morphogenetic proteins (BMPs) are
✦ LIBER ✦
Bone Morphogenetic Protein 2 Acts Synergistically with Transforming Growth Factor β3 in Endothelial-Mesenchymal Cell Transformation during Chick Heart Development
✍ Scribed by TOSHIYUKI YAMAGISHI; YUJI NAKAJIMA; T. KUBER SAMPATH; KOHEI MIYAZONO; HIROAKI NAKAMURA
- Book ID
- 111394132
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 141 KB
- Volume
- 857
- Category
- Article
- ISSN
- 0890-6564
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The bone morphogenetic protein (BMP)-2 is a potent osteoinductive signal, inducing bone formation in vivo and osteoblast differentiation from non-osseous cells in vitro. The runt domain-related protein Cbfa1/PEBP2␣A/ AML-3 is a critical component of bone formation in vivo and transcriptional regulat