Bone mineral density and knee osteoarthritis in elderly men and women. the framingham study

✍ Scribed by Marian T. Hannan; Jennifer J. Anderson; Yuqing Zhang; Daniel Levy; David T. Felson

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 820 KB
• Volume: 36
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780361205

✦ Synopsis

To examine the possible inverse relationship between osteoporosis and osteoarthritis (OA) by evaluating the association between bone mineral density (BMD) and knee OA in the Framingham Study cohort.

Methods. Of the 1,154 Framingham Study cohort subjects in whom BMD measurements were obtained at biennial examination 20, 932 (81%) had had knee OA assessed during the Framingham Knee OA Study 4 years earlier. BMD of the proximal femur and radius was measured by densitometry. Knee OA was assessed from a weight-bearing anteroposterior radiograph and graded on a scale of 0 (no OA) to 4 (severe OA). Osteophytes and joint space narrowing were also evaluated separately. Linear regression was used to test the association of BMD with knee OA, with osteophytes,