Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro
β Scribed by Din-Lii Lin; Catherine P. Tarnowski; Jian Zhang; Jinlu Dai; Emileigh Rohn; Avni H. Patel; Michael D. Morris; Evan T. Keller
- Book ID
- 118285883
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 549 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0270-4137
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## Abstract Ecological data suggest a longβterm diet high in plant material rich in biologically active compounds, such as the lignans, can significantly influence the development of prostate cancer over the lifetime of an individual. The capacity of a pure mammalian lignan, enterolactone (ENL), to
LNCaP lineage-derived human prostate cancer cell lines C4-2 and C4-2B 4 acquire androgen independence and osseous metastatic potential in vivo. Using C4-2 and C4-2B 4 the goals of the current investigation were 1) to establish an ideal bone xenograft model for prostate cancer cells in intact athymic