Bone mass in obese, goldthioglucose-treated, hyperglycaemic mice

✍ Scribed by I. De Leeuw; P. Van Rooy; M. D'Hollander

• Book ID: 104689499
• Publisher: Springer
• Year: 1981
• Tongue: English
• Weight: 295 KB
• Volume: 20
• Category: Article
• ISSN: 0012-186X
• DOI: 10.1007/bf00262018

✦ Synopsis

In contrast to insulin-dependent diabetics, bone mass in obese non-insulin dependent diabetics seems to be greater than in normal subjects. Hyperglycaemic, obese goldthioglucose mice were studied as a model for this last type of diabetes. A significantly greater cortical bone mass (cortical surface: 1.32 mm2 vs 1.15 mm2 for controls, p less than 0.01) with enhanced bone apposition was found together with a significantly greater trabecular bone mass (trabecular surface 0.17 mm2 vs 0.13 mm2, p = 0.05) increasing bone solidity. The pathogenesis is unclear but hyperinsulinism and overnutrition may be contributory factors.