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Bone Marrow Transplantation for Patients with Chronic Myeloid Leukemia

✍ Scribed by Goldman, John M.; Apperley, Jane F.; Jones, Lydia; Marcus, Robert; Goolden, Alan W.G.; Batchelor, Richard; Hale, Geoffrey; Waldmann, Herman; Reid, Cecil D.; Hows, Jill; Gordon-Smith, Edward; Catovsky, Daniel; Galton, David A.G.

Book ID
120003492
Publisher
Massachusetts Medical Society
Year
1986
Tongue
English
Weight
978 KB
Volume
314
Category
Article
ISSN
0096-6762

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## Background: The objective of this analysis was to evaluate the role of autologous stem cell transplantation (asct) in prolonging disease free survival (dfs) and overall survival (os) in patients with chronic myeloid leukemia (cml) who received autografts of philadelphia chromosome (ph) positive

Non-random involvement of chromosome 13
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Chronic myeloid leukemia (CML) patients with persistent or relapsed disease following bone-marrow transplantation (BMT) usually show both clonal and non-clonal cytogenetic changes in addition to the Philadelphia (Ph) translocation. These changes are presumably due to conditioning prior to transplant