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Bone marrow necrosis and thrombotic complications in childhood acute lymphoblastic leukemia

✍ Scribed by Eguiguren, José M. ;Pui, Ching-Hon

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
585 KB
Volume
20
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Two children with bone marrow necrosis at diagnosis or at relapse of acute lymphoblastic leukemia (ALL) had thrombotic complications 15 and 17 days after starting remission induction therapy including prednisone, vincristine, and L‐asparaginase. The close temporal relationship of these two relatively rare events suggests that bone marrow necrosis is a predisposing factor to the development of thrombosis.

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Localized bone marrow relapse in acute lymphoblastic leukemia
✍ Golembe, Sarry ;Ramsay, Norma K. C. ;McKenna, Robert ;Nesbit, Mark E. ;Krivit, W 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 793 KB

Localized bone marrow relapse is rare in acute lymphoblastic leukemia. Discordant bone marrow specimens were found in an 11-year-old asymptomatic girl who had been in remission for six years and off chemotherapy for 2 1/2 years. One bone marrow sample showed marked leukemic infiltration, whereas mar