Bone Marrow Failure

✍ Scribed by Gary M. Kupfer, Gregory H. Reaman, Franklin O. Smith

Publisher: Springer International Publishing
Year: 2018
Tongue: English
Leaves: 217
Series: Pediatric Oncology
Edition: 1st ed.
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book presents the latest scientific knowledge on inherited and acquired bone marrow failure syndromes, describing the advances in understanding of genetics and pathophysiology that have been achieved as a result of high-throughput DNA sequencing, RNA expression studies, and modern biochemistry techniques. The full range of relevant conditions is covered, including acquired aplastic anemia, Fanconi anemia, ribosomopathies, telomeropathies, dyskeratosis congenita, Shwachman-Diamond syndrome, Diamond-Blackfan anemia, and congenital neutropenias and thrombocytopenias. In addition, it is explained how the study of these rare diseases has uncovered important new science and elucidated the pathophysiology of more common hematological and oncological diseases. A treatment-specific chapter describes options ranging from the conventional to the cutting edge. Bone Marrow Failure will be of value for both trainee and practicing hematologists and oncologists.

✦ Table of Contents

Front Matter ....Pages i-ix
The Cellular and Molecular Mechanisms of Hematopoiesis (Erinn B. Rankin, Kathleen M. Sakamoto)....Pages 1-23
Acquired Aplastic Anemia (Yigal Dror, Michaela Cada)....Pages 25-55
Pediatric Myelodysplastic Syndromes (Inga Hofmann)....Pages 57-79
Fanconi Anemia: A Pathway of Hematopoiesis and Cancer Predisposition (Ali Suliman, Franklin O. Smith, Gary M. Kupfer)....Pages 81-97
Ribosomopathies Through a Diamond Lens (Anna Aspesi, Steven R. Ellis)....Pages 99-110
Dyskeratosis Congenita and the Telomere Biology Disorders (Lois Dodson, Alison A. Bertuch)....Pages 111-135
Diamond-Blackfan Anemia (Shilpa M. Hattangadi, Jeffrey M. Lipton)....Pages 137-152
Shwachman-Diamond Syndrome (Kasiani C. Myers, Akiko Shimamura)....Pages 153-164
Hematopoietic Cell Transplantation for the Treatment of Patients with Bone Marrow Failure Syndromes (Andrew C. Dietz, Michael A. Pulsipher)....Pages 165-179
Inherited Neutropenias and Their Insights into Cellular and Developmental Biology (Hrishikesh M. Mehta, Seth J. Corey)....Pages 181-192
Inherited Thrombocytopenias (Taizo Nakano, Jorge Di Paola)....Pages 193-214

✦ Subjects

Medicine & Public Health; Oncology; Pediatrics; Hematology

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