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Bone marrow examination in small cell carcinoma of the bronchus: An unnecessary procedure?

✍ Scribed by G. M. Mead; C. J. Williams; J. Thompson; A. G. Smith; J. M. A. Whitehouse

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
328 KB
Volume
3
Category
Article
ISSN
0278-0232

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✦ Synopsis

Abstract

One hundred and thirty‐seven patients with small cell carcinoma of the bronchus underwent bone marrow trephine and/or aspirate examination as part of their clinical staging. Twenty‐four patients (17.5 per cent) were found to have malignant marrow infiltration. In no case was this an isolated finding of metastatic disease, indeed most patients had gross metastatic spread to liver and/or bone. Marrow infiltration has not been shown to be a major prognostic factor in response to chemotherapy or survival in previous studies. We recommend that this staging procedure be discontinued in routine clinical practice, and instead be confined to specific indications in clinical trials.

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In small-cell carcinoma of the bronchus, extension to the brain is common. The role of prophylactic whole-brain irradiation and combination chemotherapy using CCNU in the prevention of brain extension is examined in the light of recent studies.