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Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells

✍ Scribed by Antonio Pellegrino; Roberto Ria; Giulia Di Pietro; Teresa Cirulli; Giammarco Surico; Angela Pennisi; Fortunato Morabito; Domenico Ribatti; Angelo Vacca


Book ID
108673131
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
435 KB
Volume
129
Category
Article
ISSN
0007-1048

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## Abstract MM is a B‐cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, presence of paraprotein in serum and occurrence of osteolytic bone lesions. MMPs are a family of proteolytic enzymes that can contribute to cancer growth, invasion, angiogenesis, bone degra