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Bone marrow-derived microglia contribute to the neuroinflammatory response and express iNOS in the MPTP mouse model of Parkinson's disease

✍ Scribed by Erzsebet Kokovay; Lee Anna Cunningham


Book ID
116761772
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
378 KB
Volume
19
Category
Article
ISSN
0969-9961

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN