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Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis

✍ Scribed by Tatiana Kisseleva; Hiroshi Uchinami; Nikki Feirt; Oscar Quintana-Bustamante; Jose Carlos Segovia; Robert F. Schwabe; David A. Brenner

Book ID: 116651123
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 780 KB
Volume: 45
Category: Article
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2006.04.014

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Bone marrow (BM)-derived stem cells and CD34(+) fibrocytes are associated with fibrogenesis in several organs. In an Abcb4(-/-) mouse model for sclerosing cholangitis alpha-smooth muscle actin-positive (alpha-SMA(+)) myofibroblasts are thought to play a pivotal role in hepatic fibrogenesis. The aim