✦ LIBER ✦

Bone marrow and tumour stroma: an intimate relationship

✍ Scribed by Natalie C Direkze; Malcolm R Alison

Book ID: 102259075
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 212 KB
Volume: 24
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.788

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In recent years the bone marrow has become recognized as a potential source of cells for non‐haematopoietic wound healing, in some instances demonstrating surprising plasticity in providing new epithelial cells. On the other hand, the contribution of bone marrow derived cells to fibrosis and blood vessel formation is more widely acknowledged. Tumour stroma has a vital role to play in determining cancer growth and spread, and there is a growing realization that the bone marrow has a significant input into this desmoplastic response. This review focuses on the contribution of bone marrow cells to tumour stroma, highlighting the bone marrow as a potential new portal through which to direct anti‐tumour therapies. Copyright © 2006 John Wiley & Sons, Ltd.

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