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Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

✍ Scribed by Karin E. M. Diderich, Claudia Nicolaije, Matthias Priemel, Jan H. Waarsing, Judd S. Day, Renata M. C. Brandt, Arndt F. Schilling, Sander M. Botter, Harrie Weinans, Gijsbertus T. J. van der Horst, Jan H. J. Hoeijmakers, Johannes P. T. M. van Leeuwen

Book ID
118813360
Publisher
Springer Netherlands
Year
2011
Tongue
English
Weight
583 KB
Volume
34
Category
Article
ISSN
0161-9152

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Premature Aging in Mice Deficient in DNA
Premature Aging in Mice Deficient in DNA Repair and Transcription
✍ de Boer, J. πŸ“‚ Article πŸ“… 2002 πŸ› American Association for the Advancement of Scienc 🌐 English βš– 527 KB

One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing studies of mice with a mutation in __XPD__ , a gene encoding a DNA helicase that functions in both repair and transcription and that is mutate