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Bone formation on carbon nanotube composite

✍ Scribed by Mrinal Bhattacharya; Patcharaporn Wutticharoenmongkol-Thitiwongsawet; Darryl T. Hamamoto; Dongjin Lee; Tianhong Cui; Hari S. Prasad; Mansur Ahmad

Book ID
102873702
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
573 KB
Volume
96A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

The effects of a layer‐by‐layer assembled carbon nanotube composite (CNT‐comp) on osteoblasts in vitro and bone tissue in vivo in rats were studied. The effects of CNT‐comp on osteoblasts were compared against the effects by commercially pure titanium (cpTi) and tissue culture dishes. Cell proliferation on the CNT‐comp and cpTi were similar. However, cell differentiation, measured by alkaline phosphatase activity and matrix mineralization, was better on the CNT‐comp. When implanted in critical‐sized rat calvarial defect, the CNT‐comp permitted bone formation and bone repair without signs of rejection or inflammation. These data indicate that CNT‐comp may be a promising substrate for use as a bone implant or as a scaffold for tissue engineering. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2010.

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