Bone colonization of ?-TCP granules incorporated in brushite cements

✍ Scribed by Flautre, B. ;Maynou, C. ;Lemaitre, J. ;Van Landuyt, P. ;Hardouin, P.

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 123 KB
• Volume: 63
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.10262

✦ Synopsis

Abstract

Injectable calcium phosphate hydraulic cements are known to have a high clinical potential in bone reconstruction for mini‐invasive orthopaedic surgery, interventional radiology, and rheumatology. Previous in vivo experiments in rabbit have shown that the presence of β–TCP granules in injectable bone cement help maintain the transient biomechanical function of the implanted bone and promote the formation of good‐quality new bone. Histomorphometric analysis of two brushite hydraulic cement (BHC) mixtures selected from previous results (referred to in this work as BHC–A and BHC–B) was performed at three postoperative delays (0, 12, and 24 weeks): histomorphometric analysis of bone colonization within β–TCP shows that, just before implantation, the β–TCP granule area is significantly higher in BHC–B; the residual granule area decreases steadily over time in BHC–A, whereas it goes through a maximum of 30% at 12 weeks in BHC–B; the residual granule porosity increases steadily up to 35% in BHC–A, whereas it goes through a maximum of 35% at 12 weeks and decreases somewhat until 24 weeks in BHC–B. New bone formation within granules appears higher in BHC–A (58% Area) compared to BHC–B (38% area) at 12 weeks. At 24 weeks bone colonization levels off in both cements at about 50% area. Irrespective of the cement matrix composition, β–TCP granules contribute actively to the conduction of new bone formation. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res (Appl Biomater) 63: 413–417, 2002