Bone-bonding ability of a hydroxyapatite coated zirconia–alumina nanocomposite with a microporous surface
✍ Scribed by M. Takemoto; S. Fujibayashi; M. Neo; J. Suzuki; T. Kokubo; T. Nakamura
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 517 KB
- Volume
- 78A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Using a combination of hydroxyapatite (HA) coating and microporous surface treatment, bone‐bonding ability was given to composites of ceria‐stabilized tetragonal zirconia and alumina (CZA), which possesses excellent mechanical and wear properties and phase stability. Four types of CZA plates (2 × 10 × 15 mm^3^) were prepared for this study, which were CZA with a polished surface (group 1), a microporous surface prepared by hydrofluoric acid and heat treatment (group 2), a microporous surface with a submicron HA coating prepared by alternately soaking the plate from group 2 in aqueous CaCl~2~/HCl and Na~2~HPO~4~ solutions (group 3), and a microporous surface with a 4‐μm HA coating prepared by the biomimetic method, where the plates from group 3 were soaked in simulated body fluid (group 4). Plates were implanted into rabbit tibia, and after 4, 8, and 16 weeks, tensile testing and histological examination of the bone–implant interface were conducted. At 4 weeks, group 4 had superior bone‐bonding ability compared with other implants, which was maintained at the later postimplantation times. This HA‐coated CZA with a microporous surface has the possibility of clinical use as a bearing material in cementless joint prostheses or as a load‐bearing bone substitute. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006