Bombesin derivative radiolabeled with technetium-99m as agent for tumor identification

✍ Scribed by André Luís Branco de Barros; Luciene das Graças Mota; Carolina de Aguiar Ferreira; Mônica Cristina de Oliveira; Alfredo Miranda de Góes; Valbert Nascimento Cardoso

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 243 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.08.124

✦ Synopsis

A bombesin derivative was successfully radiolabeled in high labeling yield. Biodistribution studies and scintigraphic images in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Thus, 99m Tc-HYNIC-Bombesin (7-14) could be used as an agent for tumor diagnosis.