BOLD-MRI in ten patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery
✍ Scribed by Christian M Wacker; Michael Bock; Andreas W Hartlep; Wolfgang R Bauer; Gerhard van Kaick; Stefan Pfleger; Georg Ertl; Lothar R Schad
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 363 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0968-5243
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✦ Synopsis
Changes of myocardial oxygenation can be studied by measurements of the apparent transverse relaxation time T 2 *, which is correlated with the oxygenation state of hemoglobin. In this study, ten patients with coronary artery disease (CAD) underwent blood oxygenation level dependent (BOLD) T 2 * measurements using a segmented gradient echo pulse sequence with ten echoes. T 2 * measurements were performed in a single short-axis slice of the heart at rest and under pharmacological stress with dipyridamole (DIP), which increases myocardial blood flow. For comparison, all patients underwent X-ray angiography and stress-echocardiography within 4 days after the MR exam. In one patient, MR examination was repeated 10 weeks after percutaneous transluminal coronary angioplasty (PTA). In the differential T 2 * maps, expected ischemic areas of myocardium were identified in six patients. In these regions, T 2 * values (309 8 ms) were significantly reduced when compared to the remaining myocardium (48 99 ms, P B0.01). In four patients, the myocardial region of interest could not be assessed owing to severe susceptibility artifacts in the ischemic region. The success of the PTA treatment could be visualized from a more homogeneous DIP induced increase in T 2 * within the ischemic myocardium (from 26 9 1 to 299 1 ms before PTA versus 26 9 1 to 319 4 ms after PTA, PB0.