𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Body size in relation to cancer of the uterine corpus in 1 million Norwegian women

✍ Scribed by Tone Bjørge; Anders Engeland; Steinar Tretli; Elisabete Weiderpass

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
134 KB
Volume
120
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A positive association between overweight/obesity and endometrial cancer has been observed. It has been hypothesized that obesity is mostly associated with a subtype described as estrogen‐dependent (Type I tumors), constituting about 80% of the endometrial tumors. Few epidemiologic studies have, however, analyzed different histological subtypes separately. The present study aimed at exploring the relations between body size and histological subtypes of cancer of the uterine corpus. Height and weight were measured in over 1 million Norwegian women aged 20–74 during 1963–2001. During follow‐up, 9,227 cancers of the uterine corpus were diagnosed. The tumors were classified as Type I tumors (mostly endometrial adenocarcinomas with subgroups), Type II tumors (papillary, serous, and clear cell adenocarcinomas and some poorly differentiated carcinomas), sarcomas, and mixed tumors. Relative risks (RRs) of cancer of the uterine corpus were estimated using Cox proportional hazards regression. Compared with women with normal BMI, overweight and obese women had an overall RR of cancer of the uterine corpus of 1.36 (95% CI: 1.29–1.42) and 2.51 (95% CI: 2.83–2.66). The increase in risk was most pronounced for Type I tumors, but was also seen for Type II tumors, sarcomas and mixed tumors. The overall RR of corpus uteri cancer associated with a 10‐cm increase in height was 1.09 (95% CI: 1.05–1.13), and was mostly observed for Type I tumors. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Height and weight in relation to uterine
Height and weight in relation to uterine corpus cancer in norway morbidity and mortality. A follow-up study of 570,000 women in Norway
✍ Steinar Tretli; Knut Magnus 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 676 KB

## MORBIDITY AND MORTALITY. A FOLLOW-UP STUDY OF 570,000 WOMEN The height and weight of 570,000 Norwegian women, aged ## 3-9 years, were measured and the subjects were then followed up for 6 1 8 years with regard to uterine corpus cancer morbidity and mortality. The analysis reveals that both h

Body mass index and physical activity in
Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women
✍ Miranda EG Armstrong; Elizabeth A Spencer; Benjamin J Cairns; Emily Banks; Kirst 📂 Article 📅 2011 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 261 KB 👁 2 views

## Abstract Hip fracture risk is known to increase with physical inactivity and decrease with obesity, but there is little information on their combined effects. We report on the separate and combined effects of body mass index (BMI) and physical activity on hospital admissions for hip fracture amo

TP53 alterations in relation to the cell
TP53 alterations in relation to the cell cycle-associated proteins p21, cyclin D1, CDK4, RB, MDM2, and EGFR in cancers of the uterine corpus
✍ Skomedal, Hanne; Kristensen, Gunnar B.; Nesland, Jahn M.; B�rresen-Dale, Anne-Li 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 283 KB 👁 2 views

In the present study, TP53 alterations have been analysed and compared with the expression of the proteins p21, cyclin D1, cdk4, RB, EGFR, and MDM2 in 53 cancers of the uterine corpus. TP53 gene mutations analysed by CDGE/DGGE and direct sequencing showed a TP53 gene mutation in 18 per cent of the c

Cancer of the corpus uteri in white and
Cancer of the corpus uteri in white and black women in Michigan, 1985-1994 : An analysis of trends in incidence and mortality and their relation to histologic subtype and stage
✍ Terri Madison; David Schottenfeld; Vicki Baker 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 1 views

## Background: Cancer of the corpus uteri occurs more commonly among white women in the u.s., yet survival is poorer for black women. this study examined whether this trend has changed and also examined the relation of age and histologic subtype to differences in stage. ## Methods: This retrospec