✦ LIBER ✦

Body distribution and endocrine toxicity of hexachlorobenzene (HCB) in the female rat

✍ Scribed by Warren G. Foster; Julie A. Pentick; Avril McMahon; Pierre R. Lecavalier

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 499 KB
Volume: 13
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550130203

No coin nor oath required. For personal study only.

✦ Synopsis

Hexachlorobenzene (HCB) residue levels in dosed rats (50.0 mg kg body wt. day-', n = 9 ) were significantly (P < 0.05) greater in the periovarian fat compared to the thyroid gland. Hexachlorobenzene residue levels were significantly (P < 0.05) greater in the thyroid versus the adrenal and ovary. Ovarian HCB residue levels were greater than those found in the thymus, liver and lung. Serum thyroxin (T4) and the free T4 index (FH) were significantly ( P < 0.05) suppressed in HCB-treated rats compared to the control group (n = 8). In contrast, no significant differences in serum concentrations of oestradiol (EJ, progesterone (P4) or percentage triiodothyronine uptake ( %T3) were observed, thus suggesting an HCB-induced hypothyroid-like state. In a second experiment, adult female Sprague Dawley rats (n = 16) were dosed as above and superovulated with pregnant mare serum gonadotrophin (PMSG, 10 IU s.c.) and human chorionic gonadotrophin (hCG, 20 IU s.c.). Circulating levels of P4 were significantly (P < 0.05) elevated compared to the control group (n = 8).

The %T3 uptake and serum T4 levels were significantly (P = 0.05) suppressed compared to controls.

Hexachlorobenzene treatment had no effect on circulating levels of Ez or on the FTI. These results suggest that HCB-induced changes found in the spontaneously cycling rat are augmented by ovulation induction strategies. We also conclude that HCB concentrates in the endocrine tissues in addition to the fat.

📜 SIMILAR VOLUMES

Ovarian toxicity of hexachlorobenzene (H

Ovarian toxicity of hexachlorobenzene (HCB) in the superovulated female rat

✍ Foster, Warren G. ;Pentick, Julie A. ;McMahon, Avril ;Lecavalier, Pierre R. 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB

## Abstract Hexachlorobenzene (HCB) is a persistent environmental contaminant which has been measured in human serum, fat, semen, and follicular fluid. In animal testing HCB has been shown to be a reproductive toxin. Discrepant results were obtained from prior studies concerning the effect of HCB t

Influence of chelating agents on the tox

Influence of chelating agents on the toxicity and distribution of beryllium in rats

✍ Sangeeta Shukla; Pragya Sharma; Sonia Johri; R. Mathur 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 59 KB 👁 2 views

The effect of two new chelating agents-Tiron (4,5-dihydroxy-1,3-benzene disulphonic acid disodium salt) and succinic acid-on the mobilization of beryllium was studied. Animals were exposed to beryllium nitrate (1 mg kg -1 i.p.) daily for 21 days. Administration of beryllium nitrate showed a marked d

Distribution and hormone regulation of e

Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats

✍ Weiland, N.G.; Orikasa, C.; Hayashi, S.; McEwen, B.S. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 411 KB 👁 2 views

Estrogen regulates the synaptic plasticity and physiology of the hippocampus as well as learning behaviors that are mediated by the hippocampus. The density of dendritic spines and synapses, the number of N-methyl-D-aspartate (NMDA) binding sites, the levels of NMDA receptor subunit NR1 protein, mus

Maternal-fetal distribution and prenatal

Maternal-fetal distribution and prenatal toxicity of 2,2,4-trimethyl-1,2-dihydroquinoline in the rat

✍ Krystyna Sitarek; Andrzej Sapota 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 118 KB 👁 1 views

## Abstract **BACKGROUND:** Polnoks R (poly‐2,2,4‐trimethyl‐1,2‐dihydroquinoline) is used as an antioxidant in elastomer processing. It is an embryotoxic and fetotoxic agent. This chemical given per os to female rats induces also teratogenic effect but only at doses toxic to the mother. The aim of

Identification of drug-induced hyper- or

Identification of drug-induced hyper- or hypoprolactinemia in the female rat based on general and reproductive toxicity study parameters

✍ Sabine Rehm; Dinesh J. Stanislaus; Patrick J. Wier 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB 👁 1 views

Distribution patterns of the membrane gl

Distribution patterns of the membrane glycoprotein CD44 during the foreign-body reaction to a degradable biomaterial in rats and mice

✍ Bonnema, Harmke ;Popa, Eliane R ;van Timmeren, Mirjan M. ;van Wachem, Pauline B. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB

## Abstract Although biomaterials have been used in the clinical setting for a long time, little is known of the molecular mechanisms underlying the foreign‐body reaction (FBR). A good understanding of these mechanisms is requisite for the controlled regulation of the FBR needed to prevent adverse