BMP7, a Putative Regulator of Epithelial Homeostasis in the Human Prostate, Is a Potent Inhibitor of Prostate Cancer Bone Metastasis in Vivo
✍ Scribed by Jeroen T. Buijs; Cyrill A. Rentsch; Geertje van der Horst; Petra G.M. van Overveld; Antoinette Wetterwald; Ruth Schwaninger; Niek V. Henriquez; Peter ten Dijke; Fran Borovecki; Regula Markwalder; George N. Thalmann; Socrates E. Papapoulos; Rob C.M. Pelger; Slobodan Vukicevic; Marco G. Cecchini; Clemens W.G.M. Löwik; Gabri van der Pluijm
- Book ID
- 119980937
- Publisher
- American Society for Investigative Pathology
- Year
- 2007
- Tongue
- English
- Weight
- 799 KB
- Volume
- 171
- Category
- Article
- ISSN
- 0002-9440
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📜 SIMILAR VOLUMES
## Abstract Metastasis to the bone is a major clinical complication in patients with prostate cancer (PC). However, therapeutic options for treatment of PC bone metastasis are limited. Gelatinases are members of the matrix metalloproteinase (MMP) family and have been shown to play a key role in PC
## Abstract AN‐7, a prodrug of butyric acid, induced histone hyperacetylation and differentiation and inhibited proliferation of human prostate 22Rv1 cancer cells __in vitro__ and __in vivo.__ In nude mice implanted with these cells, 50 mg/kg AN‐7 given orally thrice a week led to inhibition of tum