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BMP-4 treatment of C3H10T1/2 stem cells blocks expression of MMP-3 and MMP-13

✍ Scribed by Tamara C. Otto; Robert R. Bowers; M. Daniel Lane

Book ID
116294222
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
409 KB
Volume
353
Category
Article
ISSN
0006-291X

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The molecular mechanisms by which bone morphogenetic proteins (BMPs) promote skeletal cell differentiation were investigated in the murine mesenchymal stem cell line C3H10T1/2. Both BMP-7 and BMP-2 induced C3H10T1/2 cells to undergo a sequential pattern of chondrogenic followed by osteogenic differe