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BMK1 is involved in the regulation of p53 through disrupting the PML–MDM2 interaction

✍ Scribed by Yang, Q; Liao, L; Deng, X; Chen, R; Gray, N S; Yates, J R; Lee, J D

Book ID
120246617
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
812 KB
Volume
32
Category
Article
ISSN
0950-9232

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Wild-type p53 has a major role in the response and execution of apoptosis after chemotherapy in many cancers. Although high levels of wild-type p53 and hardly any __TP53__ mutations are found in testicular cancer (TC), chemotherapy resistance is still observed in a significant subgroup of TC patient