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BMI-1 is Highly Expressed in M0-Subtype Acute Myeloid Leukemia

✍ Scribed by Masashi Sawa; Kazuhito Yamamoto; Toshiya Yokozawa; Hitoshi Kiyoi; Asahi Hishida; Tomohiro Kajiguchi; Masao Seto; Akio Kohno; Kunio Kitamura; Yoshie Itoh; Norio Asou; Nobuyuki Hamajima; Nobuhiko Emi; Tomoki Naoe

Book ID: 111835445
Publisher: Carden Jennings Publishing
Year: 2005
Tongue: English
Weight: 260 KB
Volume: 82
Category: Article
ISSN: 0925-5710
DOI: 10.1532/ijh97.05013

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## Abstract The __AML1__ gene encodes a transcription factor that, together with its heterodimeric partner CBFB, regulates a number of target genes that are essential for normal hemopoiesis. In acute myeloid leukemia (AML), __AML1__ is disrupted not only by chromosomal translocations but also by mu