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Blood–brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses

✍ Scribed by William M. Pardridge


Book ID
113691538
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
163 KB
Volume
122
Category
Article
ISSN
0168-3659

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## Abstract Neurotrophins, such as brain derived neurotrophic factor (BDNF), do not cross the blood–brain barrier (BBB). Certain monoclonal antibodies (MAb) to the human insulin receptor (HIR) do cross the BBB via receptor‐mediated transport, and can act as a molecular Trojan horse to ferry across