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Blood–brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses

✍ Scribed by William M. Pardridge

Book ID: 113691538
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 163 KB
Volume: 122
Category: Article
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2007.04.001

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## Abstract Neurotrophins, such as brain derived neurotrophic factor (BDNF), do not cross the blood–brain barrier (BBB). Certain monoclonal antibodies (MAb) to the human insulin receptor (HIR) do cross the BBB via receptor‐mediated transport, and can act as a molecular Trojan horse to ferry across